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KMID : 1101220000320030237
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2000 Volume.32 No. 3 p.237 ~ p.244
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Morphological Changes of Cancer Cell Lines Induced by Ethanol Extracts from Green Tea
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Jang Won-Tae
Lee Hyo-Kwon
Kim Mi-Hyung
Liu Yin
Choi Won-Kyung
Sung Hoon-Ki
Park Jeong-Hyun
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Abstract
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Green tea is one of most popular traditional teas in korea. The purpose of this study was comparing the effects of ethanol extracts on three kinds of cancer cell lines(HepG2, A549, EATC) according to its concentration and exposure time. For this purpose, we observed morphological changes under inverted and electron microscope and analysed cytotoxicity . EATC(Ehrlich-Lettre Ascites Tumor Cell) cells were damaged by 100μg/ml ethanol extracts treatment until 72 hours gradually. In A549 cells, ethanol extracts caused severe cellular injury abruptly and lasted for 72 hours. However, cellular necrosis and growth inhibition in both of them could not be observed in 1, 10μg/ml ethan이 extracts administration. Whereas, the effects of that were weak in all of concentrations and exposure times in HepG2 cells. In conclusion, green tea ethanol extracts induced strong inhibition of growth and severe cellular damages in A549(LlUlg Cancer) and EATC except HepG2(Hepatoblastoma). In addition, its effects were dependent on concentration and duration of ethanol extracts. Therefore, though there were some different effect according to cancer type, it suggested that green tea would be helpful to prevent carcinogenesis and treat cancer.
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KEYWORD
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Green tea, Cancer, MTT, Electron microscope
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